Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [bulk RNA-Seq]

ABSTRACT: Transcriptomic analysis of sorted HFSCs revealed dynamic transcriptional reprogramming during inflammation, including activation of stress response and immune-modulatory genes. Pathway enrichment highlighted metabolic adaptation and signaling networks linked to stem cell activation. These findings demonstrate that HFSCs undergo intrinsic molecular changes that parallel their regenerative response.

ORGANISM(S): Mus musculus

PROVIDER: GSE306509 | GEO | 2025/12/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [spatial transcriptomics]

Project description:Using Visium HD spatial transcriptomics and immunostaining, we mapped skin compartment dynamics during DPCP-induced allergic contact dermatitis. Dermal white adipose tissue transitioned from metabolic homeostasis to immune activation and inflammatory remodeling, accompanied by sustained lipolysis. Concurrently, CD45⁺ immune cells accumulated in the lower dermis and dWAT. These findings identify dWAT as an immune-metabolic hub orchestrating inflammatory progression and highlight spatial transcriptomics as a powerful tool for dissecting skin niche regulation.

2025-12-01 | GSE306162 | GEO

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-12-01 | GSE306678 | GEO

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [scRNA-Seq]

Project description:Skin inflammation involves complex interactions between immune cells. To address this gap, we applied single-cell RNA sequencing to dissect cellular states and regulatory programs in DPCP-induced dermatitis. This approach enables high-resolution mapping of immune crosstalk and identification of novel macrophage subsets. Our study establishes a framework for understanding how immune and metabolic signals orchestrate skin inflammation and regeneration.

2025-12-01 | GSE306510 | GEO

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity

Project description:SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity

| PRJNA1311613 | ENA

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [scRNA-Seq]

Project description:SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [scRNA-Seq]

| PRJNA1311019 | ENA

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [spatial transcriptomics]

Project description:SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [spatial transcriptomics]

| PRJNA1309625 | ENA

SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [bulk RNA-Seq]

Project description:SPP1+ Macrophages Contribute to Hair Growth in Contact Hypersensitivity [bulk RNA-Seq]

| PRJNA1311013 | ENA

Essential role of macrophages in contact hypersensitivity-induced hair regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-08 | GSE243089 | GEO

Obesity accelerates hair thinning in stem cell-centric converging mechanism

Project description:Obesity, a worldwide epidemic, predisposes to many ageing-associated diseases, yet its exact impact on organ dysfunction is largely unknown. Hair follicles, mini-epithelial organs that grow hair, miniaturize by ageing to cause hair loss through the depletion of hair follicle stem cells (HFSCs). Here, we report that obesity-induced stress such as by high-fat diet (HFD) feeding primarily targets HFSCs to accelerate hair thinning. Chronological gene expression analysis revealed that HFD feeding for four consecutive days directs activated HFSCs toward epidermal keratinization by generating excessive reactive oxygen species yet retains HFSC pools in young mice. Integrative analysis with stem cell fate tracing, epigenetic analysis and reverse genetics revealed that further feeding of HFD subsequently induces lipid droplets and NF-κB activation within HFSCs via autocrine/paracrine IL1R signaling. Those integrated factors converge on the profound inhibition of Sonic hedgehog (Shh) signal transduction in HFSCs, thereby further depleting lipid-laden HFSCs from the skin surface and inducing hair follicle miniaturization and eventual hair loss. Conversely, Shh activation by transgenes or compounds rescues HFD-induced hair loss. These data collectively demonstrate that stem cell inflammageing induced by obesity robustly represses organ regeneration signals to accelerate the mini-organ miniaturization, and indicates suggests the importance of daily prevention of organ dysfunction.

2021-04-14 | GSE131958 | GEO

Obesity accelerates hair thinning by stem cell-centric converging mechanism [RNA-seq]

Project description:Obesity, a worldwide epidemic, predisposes to many ageing-associated diseases, yet its exact impact on organ dysfunction is largely unknown. Hair follicles, mini-epithelial organs that grow hair, miniaturize by ageing to cause hair loss through the depletion of hair follicle stem cells (HFSCs). Here, we report that obesity-induced stress such as by high-fat diet (HFD) feeding primarily targets HFSCs to accelerate hair thinning. Chronological gene expression analysis revealed that HFD feeding for four consecutive days directs activated HFSCs toward epidermal keratinization by generating excessive reactive oxygen species yet retains HFSC pools in young mice. Integrative analysis with stem cell fate tracing, epigenetic analysis and reverse genetics revealed that further feeding of HFD subsequently induces lipid droplets and NF-B activation within HFSCs via autocrine/paracrine IL1R signaling. Those integrated factors converge on the profound inhibition of Sonic hedgehog (Shh) signal transduction in HFSCs, thereby further depleting lipid-laden HFSCs through their aberrant differentiation and inducing hair follicle miniaturization and eventual hair loss. Conversely, Shh activation by transgenes or compounds rescues HFD-induced hair loss. These data collectively demonstrate that stem cell inflammageing induced by obesity robustly represses organ regeneration signals to accelerate the mini-organ miniaturization, and suggests the importance of daily prevention of organ dysfunction.

2021-04-14 | GSE169173 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data