NMN protects cisplatin induced AKI via NAD+/SIRT1 pathway

ABSTRACT: Acute kidney injury (AKI) is a critical public health concern with high morbidity and mortality.Using male mice and HK-2 cells, we found that the NAD⁺ precursor NMN restored renal NAD⁺ levels and activated SIRT1, markedly lowering plasma creatinine and BUN, reducing NGAL and KIM-1 expression, suppressing IL-6/IL-18 and neutrophil infiltration, and attenuating ROS and LDH release. Thus, NMN protects against CIS-AKI via the NAD⁺–SIRT1 pathway and represents a promising therapeutic strategy.

ORGANISM(S): Mus musculus

PROVIDER: GSE306603 | GEO | 2026/01/01

REPOSITORIES: GEO