Clinical, genomic, and spatial transcriptomic features of pancreatic adenosquamous carcinoma

ABSTRACT: Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive disease variant, accounting for 1-4% of all exocrine pancreatic malignancies. Compared to conventional pancreatic ductal adenocarcinoma (PDAC), the clinical and molecular characteristics of PASC remain poorly defined due to its understudied nature. To investigate the spatial biology of PASC, we profiled resected tissue specimens from patients in our institutional cohort using the Visium spatial transcriptomics platform for compartment-specific differential gene expression and pathway enrichment analyses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE306617 | GEO | 2026/08/11

REPOSITORIES: GEO