An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS [multiome]

ABSTRACT: To uncover molecular determinants of motor neuron degeneration and selective vulnerability in amyotrophic lateral sclerosis (ALS), we performed longitudinal single-nucleus RNA sequencing, paired single-nucleus RNA and ATAC sequencing, and MERFISH spatial transcriptomics from control and SOD1-G93A mouse spinal cords. For the final snRNA-seq analysis, control experiments from Blum et al., Nat Neurosci, 2021 (GEO accession: GSE161621) were also used.

ORGANISM(S): Mus musculus

PROVIDER: GSE306675 | GEO | 2025/08/27

REPOSITORIES: GEO