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Gene expression profile of intratumoral Tregs in a FOXP3 humanized mice

ABSTRACT: We have performed a single cell sequencing assay by using DNBelab C high-throughput single-cell RNA-seq system to study intratumoral Treg cells. Treg cells promote tumorigenesis by suppressing immune responses against tumor. FOXP3 protein is the master controller of Treg function. In human, FOXP3 gene produces two isoforms by the alternative splicing of exon 2. However, mouse only produces full-length FOXP3. This study analyzed the gene expression profile of intracellular Treg cells from wild-type mice or Foxp3 humanized mice which produce both full-length and exon 2-skipped FOXP3 protein.

ORGANISM(S): Mus musculus

PROVIDER: GSE306731 | GEO | 2026/06/03

REPOSITORIES: GEO

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