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Multi-omics Approaches Revealing Bile Acid Metabolism Dysregulation in Abdominal Aortic Aneurysm Pathogenesis

ABSTRACT: Transcriptional profiling of infrarenal abdominal aortic tissue from male 8-week-old C57BL/6J mice after AAA induction via elastase adventitial incubation combined with β-aminopropionitrile administration, compared with sham-operated mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE307053 | GEO | 2026/02/11

REPOSITORIES: GEO

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Project description:Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this model, and compare with miRNA profiling performed using the same tissue. Two condition experiment, one infrarenal aorta per array. Sham vs. PPE at Day 7 post-operatively. Total 10 arrays: 5 sham D7, 5 PPE D7.

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