Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE307351 | GEO | 2026/06/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [II]

Project description:Cellular atlases reveal diverse cellular phenotypes, but how cells traverse this phenotypic landscape to impact tissues requires systematic study. We present an alveolosphere screening platform for investigating interactions between lung epithelial stem cells and their fibroblast niche. We assessed the role of 201 candidate genes in stem cells via imaging, then used RNAseq analysis for a transcriptome-wide understanding of cell-autonomous effects on stem cells and non-cell-autonomous effects on the niche. This phenome-transcriptome map uncovered new cellular states and pathways regulating stem cell growth, metabolism, and immune signaling. Notably, stem cells influenced scar-forming and immune programs in fibroblasts. This injury response was dependent on stem cell identity; loss of Nkx2.1, the transcription factor conferring lung epithelial identity, disrupted stem cell-niche interactions and had a greater non-cell-autonomous effect than eliminating the cancer genes Trp53, Egfr, or Cdkn2b. Our study highlights how functional atlases complement the cellular diversity revealed by descriptive methods.

2026-06-29 | GSE307128 | GEO

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [I]

2026-06-29 | GSE307112 | GEO

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions

Project description:Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions

| PRJNA1315700 | ENA

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [I]

Project description:Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [I]

| PRJNA1314575 | ENA

Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [II]

Project description:Mapping the Dialogue: Decoding Alveolar Stem-Niche Interactions [II]

| PRJNA1314603 | ENA

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-01 | E-GEOD-81182 | biostudies-arrayexpress

Genome-wide mapping of promoter-enhancer interactions with HiCap

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-07-06 | E-GEOD-60495 | biostudies-arrayexpress

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-07-01 | GSE81182 | GEO

Gammaherpesviruses reprogram long-term myelopoiesis through CD8⁺ T cell–monocyte dialogue within the bone marrow niche

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-03-17 | GSE324641 | GEO

Molecular dialogue between Phaseolus vulgaris seed and Xanthomonas (Xcf) bacteria interactions during seed transmission

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-01 | GSE227421 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data