Iron excess limits HHIPL2 gene expression and decreases osteoblastic activity in human MG-63 cells

ABSTRACT: Our transcriptomic data shows that iron impact on human osteoblastic MG-63 cells by decreasing HHIPL-2 gene expression (2 fold ratio). This impact is corrected in presence of deferoxamine. Additional biological experiments in the manuscript suggest that the iron related modulation of HHIPL-2 gene expression could take place in the decrease of osteoblastic markers in the MG-63 cell line. Such mechanisms could participate to the development of osteoporosis in iron overloaded patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30774 | GEO | 2012/09/01

SECONDARY ACCESSION(S): PRJNA144325

REPOSITORIES: GEO