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Methylation-based cellular deconvolution of triple-negative breast cancer DNA reveals prognostic immune signature

ABSTRACT: In triple negative breast cancer (TNBC), immune infiltration is now recognised as playing an important role in prognosis. DNA methylation, due to its cell-type specificity, offers a promising approach for quantifying immune cell abundance as a biomarker for risk stratification. Here, we used EpiDISH, a DNA methylation-based cellular deconvolution method, to estimate immune cell proportions from genome-wide methylation data across three independent cohorts, including TNBC patients. We show that increased immune cell percentage in TNBC patients specifically, was associated with longer disease-specific survival, highlighting the potential of DNA methylation-based estimates of cell composition for prognosis in TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE308164 | GEO | 2026/01/19

REPOSITORIES: GEO

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