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Gene expression profile of NK cells sorted from the lymph node of tumor free C57BL/6J mice and tumor bearing lymph node in Diffuse large B cell lymphoma model of lymphatic or hematogenous.

ABSTRACT: The cellular components of the tumor microenvironment (TME) in non-Hodgkin B cell lymphoma demonstrate remarkable diversity. Recent evidence suggests that the spatial organization of malignant, immune and stromal cells within the TME is associated with clinical outcome and response to therapy. Yet, whether tumor cells distribution within the distinct nodal compartments, following lymphatic or hematogenous dissemination further influence the shaping of the TME and the antitumoral immune response remains unclear. We used Bulk RNA sequencing to analyze the diversity transcriptomic profiles of NK cells in 3 different conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE308924 | GEO | 2026/03/23

REPOSITORIES: GEO

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