Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer [LACE-seq]

ABSTRACT: We identify four transcriptionally and spatially distinct CAF subtypes with differential immune associations across histological and infection-defined subtypes of GC. Notably, in H. pylori-positive tumors, THBS1+ CAFs exhibit a strong spatial association with regulatory T cells and are linked to local immunosuppression via WNT-FZD interactions. In parallel, the RNA-binding protein ZFP36 post-transcriptionally represses FN1 expression, thereby attenuating FN1+ CAF-mediated cytotoxic T cell engagement.

ORGANISM(S): Homo sapiens

PROVIDER: GSE309051 | GEO | 2025/12/04

REPOSITORIES: GEO