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Potential peptide drug with LCCL core motif differentiating M1 macrophage

ABSTRACT: Cochlin, encoded by the COCH gene, mediates innate immunity against bacterial infections by segregating pathogens and recruiting immune cells through its N-terminal LCCL domain. This domain is cleaved and secreted to attract macrophages and neutrophils, but its core motif has remained unclear. Here, we identified a 62–amino acid core LCCL (cLCCL) containing conserved structural elements. RNA-seq in RAW264.7 cells showed that both LCCL and cLCCL peptides induced M1 polarization, with upregulation of TICAM2, CD40, and CD86. Thus, cLCCL drives pro-inflammatory macrophage polarization and represents a promising candidate for antibacterial peptide therapeutics

ORGANISM(S): Mus musculus

PROVIDER: GSE309342 | GEO | 2025/10/01

REPOSITORIES: GEO

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Potential peptide drug with LCCL core motif differentiating M1 macrophage

Project description:Potential peptide drug with LCCL core motif differentiating M1 macrophage

| PRJNA1335205 | ENA

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