Investigation of the Regulatory Mechanism of Dhx37 in Sertoli Cells Using snRNA-seq

ABSTRACT: To investigate the regulatory mechanism of Dhx37 in Sertoli cells, snRNA-seq analysis was performed on testicular cells isolated from whole testes of wild-type and Dhx37-/- mice (CKO)at P60. After quality control, single-cell transcriptomes for both wild-type and Dhx37-/- mice were obtained. UMAP dimension reduction and visualization categorized the cells into ten distinct clusters: Round Spermatids, Elongating Spermatids, Spermatocytes, Spermatogonia, Leydig cells, Fibroblasts, Sertoli cells, Macrophages, Endothelial cells, and others, based on known marker genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE309389 | GEO | 2025/10/02

REPOSITORIES: GEO