Single-cell RNA sequencing of lung cells from bleomycin-induced and doxycycline-inducible TGF-β transgenic mouse models of pulmonary fibrosis

ABSTRACT: This study aimed to elucidate how epithelial–macrophage interactions contribute to pulmonary fibrosis. Using bleomycin-induced and genetic mouse models (Mif-2 KO, SPC-Cul3 KO, SPC-Mif KO, CX3CR1-Cd74 KO, PF4-Cd74 KO, and TGF-β transgenic mice), we performed single-cell transcriptomic profiling of lung cells and compared them with wild-type controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE309471 | GEO | 2025/11/03

REPOSITORIES: GEO