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Assessing Senescence in ASC Product and Discovery of Potential Biomarkers

ABSTRACT: Adipose-tissue derived stromal cells (ASC) are used in advanced therapy medicinal products due to their regenerative and immunomodulatory properties. Increasing the number of dosages derived from each donor product is essential to reduce variability and improve scalability of cell therapy. However, extended in vitro expansion may induce cellular senescence, potentially compromising therapeutic efficacy. This study aimed to assess the remaining proliferative potential of a cryopreserved ASC product and identify robust transcriptomic biomarkers of senescence.

ORGANISM(S): Homo sapiens

PROVIDER: GSE309666 | GEO | 2026/03/11

REPOSITORIES: GEO

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Assessing Senescence in ASC Product and Discovery of Potential Biomarkers

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