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Single-nucleus RNA-seq of gonadotropin-releasing hormone 3 (GnRH3) neurons in 7 day-post-fertilization (dpf) Tg(gnrh3:EGFP) zebrafish

ABSTRACT: We applied a single-nucleus RNA sequencing approach using 10x Genomics snRNA-seq to examine the developmental heterogeneity of GnRH3 neurons in 7 dpf zebrafish. GnRH3 serves as the key hypophysiotropic regulator of reproduction, yet the heterogeneity within its migratory neuronal population has remained unclear in 7 dpf zebrafish. By profiling nuclei from 7 dpf Tg(gnrh3:EGFP) larvae, this study provides the first single-cell-transcriptomic characterization of migrating GnRH3 neurons in 7 dpf zebrafish and offers new insights into their developmental organization and functional specialization.

ORGANISM(S): Danio rerio

PROVIDER: GSE309816 | GEO | 2026/07/15

REPOSITORIES: GEO

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