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Integrated sudden origin of complex N2-fixing cells upon global oxygenation

ABSTRACT: Origin of a novel organ or specialized cell can be considered as a process by which the underlying gene regulatory network (GRN) was organized. Large changes in this process could be caused by co-option of functional modules to novel locations or re-wiring of the regulatory networks, through alterations in cis-regulatory elements and recruitment of new regulatory factors. Here, we show the role of an evolutionary coordinator in the integrated sudden origin of complex N2-fixing cells in multicellular cyanobacteria, called heterocysts, during the Neoproterozoic Oxygenation Event (NOE). We employed ChIP-seq and a synthetic Anabaena transcription system in Escherichia coli to systematically analyze the gene regulatory relationships. The GRN of heterocyst differentiation (het-GRN) and the ancestral primitive GRN were successfully reconstructed.

ORGANISM(S): Nostoc sp. PCC 7120 = FACHB-418

PROVIDER: GSE310072 | GEO | 2025/11/20

REPOSITORIES: GEO

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