Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

ABSTRACT: To investigate the effect of TRIM28 inhibition on global transcriptomics profile in Atrx + murine NPC

ORGANISM(S): Mus musculus

PROVIDER: GSE310259 | GEO | 2026/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

Project description:To investigate the role of cohesins in murine neuroprogenitor model (Tp53-/-, Atrx+; Tp53-/-, Atrx -/-)

2026-04-15 | GSE328095 | GEO

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [Hi-C]

Project description:To investigate the 3D genome topology in murine neuroprogenitor model (Tp53-/-, Atrx+; Tp53-/-, Atrx -/-)

2026-07-01 | GSE311385 | GEO

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [CTCF CUT&TAG]

Project description:Our analysis reports increase in CTCF occpancy in Atrx- murine NPCs as compared to Atrx+ cells

2026-07-01 | GSE309142 | GEO

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

Project description:ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

| PRJNA1453908 | ENA

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

Project description:ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin

| PRJNA1365654 | ENA

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [Hi-C]

Project description:ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [Hi-C]

| PRJNA1369381 | ENA

ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [CTCF CUT&TAG]

Project description:ATRX inactivation disrupts global chromatin state and topology to dysregulate neurodevelopmental pathways in glioma cells of origin [CTCF CUT&TAG]

| PRJNA1334218 | ENA

The chromatin remodeler ATRX binds to atypical chromatin domains at the 3â exons of ZNF genes to preserve H3K9me3 enrichment

Project description:Here, we report that ATRX co-localizes with the H3K9-methyl transferase SETDB1 (also known as ESET), the co-repressor TRIM28 (also known as KAP1), and the transcription factor ZNF274 at 3â exons of Zinc Finger Genes (ZNFs) containing an atypical H3K9me3/H3K36me3 chromatin signature. Disruption of ATRX and ZNF274 leads to a significant reduction of H3K9me3, particularly at the 3â ZNF exons and other atypical chromatin regions, higher percentages of DNA damage, and defects in cell cycle. Taken together, our studies suggest that ATRX binds the 3â exons of ZNFs to maintain genomic stability through the regulation of their H3K9me3 levels XL-MNase ChIP-seq of ATRX was performed in the erythroleukemic cell line K562 and the Neuroblastoma cell line LAN6. Two independent replicates using different ATRX antibodies were performed in K562. Additionally, Native ChIP-seq of H3K9me3 in LAN6, ATRX WT and ATRX KO K562 cells was performed. Input samples were sequenced as control.

2016-04-05 | E-GEOD-70920 | biostudies-arrayexpress

Alternative Lengthening of Telomeres (ALT) and ATRX inactivation in high grade pediatric osteosarcomas

Project description:DNA microarrays were used to define the transcriptional profiles of tumor samples to compare 12 high-grade pediatric osteosarcoma tumor samples on their ALT and ATRX status.

2022-07-12 | E-MTAB-11743 | biostudies-arrayexpress

The chromatin remodeler ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment

2016-04-05 | GSE70920 | GEO