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YBX1 regulates cellular homeostasis to prevent inflammation

ABSTRACT: Tolerance of endogenous nucleic acids is crucial for cellular homeostasis and when perturbed can lead to immune dysregulation. RNA-binding proteins (RBPs) bind, modify and compartmentalize endogenous RNAs to prevent their recognition by the innate immune system. We discovered that loss of a highly abundant RBP, the cold shock domain containing Y-box binding protein 1 (YBX1), results in the spontaneous induction of an IL6/STAT3 inflammatory response and the upregulation of interferon-stimulated genes (ISGs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE310735 | GEO | 2025/12/01

REPOSITORIES: GEO

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