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Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE310933 | GEO | 2026/01/09

REPOSITORIES: GEO

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Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [RNA-Seq]

Project description:Neuronal activity induces gene expression programs associated with plasticity in the brain, but it also transiently suppresses gene expression through poorly understood mechanisms. Here, we report that neuronal activity downregulates NEUROD-dependent gene expression in cerebellar granule neurons in adult mice. Using NEUROD1/2 double conditional knockout mice of both sexes, we show that NEUROD binds and activates its target gene enhancers and establishes a three-dimensional genome architecture that facilitates transcription when neuronal activity is low. Moreover, NEUROD antagonizes activity-dependent gene expression programs, including those regulated by MEF2. However, when granule neurons are activated, NEUROD-dependent transcriptional and genome organizing functions are disrupted. Together, these findings reveal NEUROD as a key regulator of transcriptional programs associated with inactive neurons. Our study provides new insights into how neuronal activity reshapes gene transcription and genome architecture in the brain.

2026-01-09 | GSE310753 | GEO

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [Hi-C]

2026-01-09 | GSE310752 | GEO

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [ChIP-Seq]

2026-01-09 | GSE310749 | GEO

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization

Project description:Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization

| PRJNA1367568 | ENA

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [RNA-Seq]

Project description:Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [RNA-Seq]

| PRJNA1367027 | ENA

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [Hi-C]

Project description:Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [Hi-C]

| PRJNA1367028 | ENA

Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [ChIP-Seq]

Project description:Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [ChIP-Seq]

| PRJNA1367031 | ENA

Wash regulates lamin-dependent nuclear genome organization

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-03-10 | GSE59854 | GEO

RECQL5 Controls Transcript Elongation and Suppresses Transcription-Associated Genome Instability

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-09 | E-GEOD-49134 | biostudies-arrayexpress

Neuronal activity regulates the nuclear proteome to promote activity-dependent transcription.

Project description:The formation and plasticity of neuronal circuits relies on dynamic activity-dependent gene expression. Although recent work has revealed the identity of important transcriptional regulators and of genes that are transcribed and translated in response to activity, relatively little is known about the cell biological mechanisms by which activity alters the nuclear proteome of neurons to link neuronal stimulation to transcription. Using nucleus-specific proteomic mapping in silenced and stimulated neurons, we uncovered an understudied mechanism of nuclear proteome regulation: activity-dependent proteasome-mediated degradation. We found that the tumor suppressor protein PDCD4 undergoes rapid stimulus-induced degradation in the nucleus of neurons. We demonstrate that degradation of PDCD4 is required for normal activity-dependent transcription and that PDCD4 target genes include those encoding proteins critical for synapse formation, remodeling, and transmission. Our findings highlight the importance of the nuclear proteasome in regulating the activity-dependent nuclear proteome and point to a specific role for PDCD4 as a regulator of activity-dependent transcription in neurons.

| S-EPMC8504181 | biostudies-literature

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