Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis using the ureters of normal and ureteritis mice

ABSTRACT: Analysis of ureters of idiopathic ureteritis mice. The B cell functions associated genes were upregulated in the diseased ureters compared to nomal ureter. These results provide a basical information of molecular pathology in idiopathic ureteritis.

ORGANISM(S): Mus musculus

PROVIDER: GSE31098 | GEO | 2011/08/02

SECONDARY ACCESSION(S): PRJNA144687

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression analysis using the ureters of normal and ureteritis mice

Project description:Analysis of ureters of idiopathic ureteritis mice. The B cell functions associated genes were upregulated in the diseased ureters compared to nomal ureter. These results provide a basical information of molecular pathology in idiopathic ureteritis. In the study, the normal ureter (n=3) and diseased ureter (n=3) were used. The total RNA sample of each group was collected to 1 sample, 36,142 genes expressions were compared between these groups.

2011-08-01 | E-GEOD-31098 | biostudies-arrayexpress

Analysis of embryonic day E14.5 and E16.5 mouse ureters from Tshz3LacZ/LacZ mutants and wild types

Project description:In the urinary tract, smooth muscle (SM) is present in the renal pelvis, the ureter, the bladder and the urethra and plays a crucial role in the functional and structural integrity of these organs. In Tshz3 mutant ureters the myogenic program is not activated in the proximal region due to the absence of expression of myocardin (Myocd), a key regulator of SM differentiation. We set out to characterize TSHZ3-dependent mechanisms that participate to the process of ureteric smooth muscle cells (SMC) differentiation. To this aim, we used microarrays to identify distinct classes of up- and down-regulated genes in Tshz3LAcZ/LacZ mutant ureters at two different time points; at E14.5, which corresponds to the onset of the myogenic program and at E16.5, when SMC express the full repertoire of differentiation marker genes. Mouse embryonic (E14.5 and E16.5) wild type and Tshz3LacZ/LacZ mutant ureters were dissected for RNA extraction and hybridization on Affymetrix microarrays.

2013-02-01 | E-GEOD-43940 | biostudies-arrayexpress

Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial transitional cell carcinomas

Project description:The mammalian ureter contains a water-tight epithelium surrounded by smooth muscle. Key molecules have been defined which regulate ureteric bud initiation and drive the differentiation of ureteric mesenchyme into peristaltic smooth muscle. Less is known about mechanisms underlying the developmental patterning of the multilayered epithelium characterising the mature ureter. In skin, which also contains a multilayered epithelium, cytokeratin 15 (CK15), an intermediate filament protein, is a marker for cells whose progeny contribute to epidermal regeneration following wounding. Moreover, CK15+ precursor cells in skin can give rise to basal cell carcinomas. In the current study, using transcriptome microarrays of embryonic wild type mouse ureters, we detected Krt15, coding for CK15.

2013-12-01 | E-MEXP-3929 | biostudies-arrayexpress

Mouse ureter: wild type vs miR-143/145 knock out

Project description:mRNA profiling of mouse ureters comparing wild-type ureter vs. ureters from mice having whole body deletion of miR-143 and miR-145 which results in abnormal ureter peristalsis and hydronephrosis We used microarrays to detail the global program of gene expression in wild-type and miR-143/145-deficient ureters which revealed dysregulation of genes linked to smooth muscle morphology and function.

2014-10-08 | GSE58274 | GEO

Analysis of embryonic day E14.5 and E16.5 mouse ureters from Tshz3LacZ/LacZ mutants and wild types

2013-02-01 | GSE43940 | GEO

Mouse ureter: wild type vs miR-143/145 knock out

2014-10-08 | E-GEOD-58274 | biostudies-arrayexpress

scRNA sequencing analysis for human ureters and patient derived ureter oragnoid

Project description:scRNA sequencing analysis for human ureters and patient derived ureter oragnoid

| PRJNA763198 | ENA

Ureter proteomics analysis following stent placement and removal in a porcine model

Project description:Symptoms including pain and discomfort commonly present during ureteral stenting is not well understood. We investigated global changes in ureters at the transcriptional, translational, and functional levels while stents are indwelling and following removal and recovery using a porcine model. Polaris stents (6Fr, Boston Scientific, Natick, MA) were cystoscopically inserted with placement confirmed using fluoroscopy. For proteomics samples, ureters were stented for 14 days and recovered for 7 days and each pig was stented unilaterally so that the contralateral unstented kidney and ureter served as an internal control.

2023-05-10 | PXD038161 | Pride

Visium spatial gene expression analysis for human ureters

Project description:Tissue engineering offers a promising treatment strategy for ureteral strictures. Successful ureter engineering is necessitated by detailed understanding of the tissue architecture, cellular heterogeneity, and signaling pathways underlying regeneration. We define and spatially map cell populations within the human ureter by using a combinatorial approach: single-cell RNA sequencing, 10X Visium spatial transciptomics, and immunofluorescence. The stromal and urothelial cell populations are analyzed in detail, and we infer potential cell-cell communication networks underpinning the bi-directional crosstalk between these compartments. Specifically, we analyze and experimentally validate the importance of Sonic Hedgehog (SHH) signaling pathway in adult stem cell maintenance. The SHH-expressing basal cells support organoid generation in vitro, and accurately predict the differentiation trajectory of basal stem cells, to terminally differentiated umbrella cells, in vivo. Our results highlight essential processes involved in adult ureter tissue homeostasis, and provide a toolkit for guiding ureter tissue engineering.

2022-03-31 | GSE184112 | GEO

Experimental overactivity or blockade of transforming growth factor-B each generate a specific ureter malformation

Project description:The mammalian ureter is a tube connecting the kidney with the urinary bladder. The differentiated urothelial tube is surrounded by smooth muscle cells (SMCs). In mice embryos by E15, the first SM cells have formed and, over the next few prenatal days, the ureter becomes a functional unit, transmitting urine generated by the metanephros. Molecules in the transforming growth factor-beta (TGFB) axis have been reported to be upregulated in both kidney and ureter malformations. This study reports the effects of TGFB1 treatment on E15 mouse ureters in vitro.

2019-08-07 | E-MTAB-7395 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data