Sensitive CAR T cells redefine targetable CD70 expression in solid tumors [ATAC-seq]

ABSTRACT: CD70 expression in solid tumors is heterogeneous. We demonstrate that cells appearing CD70-negative retain ultra-low levels of CD70 expression. These cells that appear negative by conventional detection methods. Bulk ATAC-seq analysis of FACS-sorted CD70⁻ and CD70⁺ tumor populations revealed differential chromatin accessibility, indicating epigenetic regulation of CD70 expression in both ccRCC and HGSOC models.

ORGANISM(S): Homo sapiens

PROVIDER: GSE311096 | GEO | 2026/02/26

REPOSITORIES: GEO