Transcriptomics

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Single-cell RNA sequencing of mouse brain immune cells following peripheral SARS-CoV-2 infection


ABSTRACT: NeuroPASC, characterized by persistent neurological and neuropsychiatric symptoms, is among the most common manifestations of Post-Acute Sequelae of COVID-19 (PASC). However, the mechanisms underlying neuroPASC remain poorly understood. This dataset was generated to characterize transcriptional changes in brain immune cells following peripheral SARS-CoV-2 infection at 6, 30, and 100 days post-infection. It provides insight into the dynamic roles of brain-resident microglia and border-associated macrophages, as well as infiltrating monocytes and neutrophils, during the development and progression of neuroPASC.

ORGANISM(S): Mus musculus

PROVIDER: GSE311097 | GEO | 2026/01/21

REPOSITORIES: GEO

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