Effect of HNF1A-MODY in glucagon expressing cells in the duodenal intestine [Bulk RNA-seq]
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ABSTRACT: This project investigates the impact of the Hnf1a hotspot mutation similar to HNF1A-MODY (Maturity-Onset Diabetes of the Young) on glucagon expressing cells in the intestine. RNA sequencing (RNA-seq) data was preformed on intestinal crypts isolated from duodenum from mutant and control Hnf1a mice to study the mutation's effect on gene expression. By comparing the transcriptomcis profiles of these crypts, the study aims to uncover molecular mehcnaisms underlying the phenotype caused by HNF1A-MODY during adulhood.
ORGANISM(S): Mus musculus
PROVIDER: GSE311839 | GEO | 2026/05/29
REPOSITORIES: GEO
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