Transcriptome analysis of mouse lungs following environmentally relevant low-dose PFOS exposure in mice

ABSTRACT: Epidemiological studies suggest a potential link between PFOS exposure and reduced lung function in humans, but experimental evidence remains limited. To explore the molecular effects of environmentally relevant PFOS exposure, we examined lung transcriptional responses following chronic low-dose exposure in mice. Transcriptomic analysis revealed a set of differentially expressed genes in PFOS-exposed lungs. Functional enrichment indicated that these genes were primarily associated with immune-related processes, including immune system activity, immunoglobulin complexes, and chemokine or immunoglobulin receptor interactions. These findings suggest that low-dose PFOS exposure may influence early immune-related molecular pathways in the lung.

ORGANISM(S): Mus musculus

PROVIDER: GSE312025 | GEO | 2026/09/11

REPOSITORIES: GEO