Immune landscape of the affected brain in Rasmussen encephalitis

ABSTRACT: Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive brain atrophy. We used single cell RNA sequencing to define the types of immune cells in affected brain tissue removed to control seizures. Our analysis highlights the complexity of the immune landscape in brain areas affected by RE and supports the involvement of clonally expanded antigen experienced resident memory CD8 T cells in the etiology of the disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE312319 | GEO | 2026/01/23

REPOSITORIES: GEO