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Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging

ABSTRACT: To investigate the role S100A7, a skin-derived antimicrotial peptide (AMP) in skin aging, we knockdowned S100A7 in normal human keratinocytes, which induced senescence markers, impaired autophagy, and partially recapitulated aging-associated transcriptional changes. Conversely, supplementation with physiological levels of S100A7 restored autophagic flux and attenuated senescence in D-galactose–induced aging models. These findings identify S100A7 as a molecular link between epidermal differentiation, autophagy, and cellular senescence, establishing an AMP–autophagy axis in skin aging.

ORGANISM(S): Homo sapiens

PROVIDER: GSE312362 | GEO | 2026/01/18

REPOSITORIES: GEO

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	GSE312362_All_samples_raw_counts.txt.gz	Txt
	GSE312362_All_samples_tpm.csv.gz	Csv

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