Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The miRNA expression profiles in exosomes derived from M0 macrophages (M0-Exo) and M2 macrophages (M2-Exo).

ABSTRACT: Macrophage-derived exosomes hold significant promise for clinical disease therapy. Macrophages can be categorized into several subtypes. The resting state is known as the M0 subtype, and the exosomes they secrete are termed M0-Exo. Macrophages can be polarized to the M2 subtype by combined induction with IL-4 and IL-13, and the exosomes derived from M2 macrophages are referred to as M2-Exo. miRNAs are important cargo within exosomes. Since both M0-Exo and M2-Exo exhibit therapeutic effects in inflammatory responses, we performed miRNA sequencing on the contents of M0-Exo and M2-Exo to investigate the underlying mechanisms of their therapeutic actions.

ORGANISM(S): Mus musculus

PROVIDER: GSE312882 | GEO | 2026/01/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comprehensive analysis of M2 macrophage-derived exosomes facilitating osteogenic differentiation of human periodontal ligament stem cells

Project description:As the primary seed cells in periodontal tissue engineering, the role of periodontal ligament stem cells (PDLSCs) in periodontal tissue regeneration and bone remodeling during orthodontic tooth movement (OTM) has been well documented. Nevertheless, the impact of different polarization states of macrophages on the osteogenic differentiation of PDLSCs is poorly understood. M0, M1 and M2 macrophage-derived exosomes (M0-exo, M1-exo and M2-exo) were treated with primary cultured human PDLSCs, respectively. Identification of differentially expressed microRNAs (DE-miRNA) in M0-exo and M2-exo by miRNA microarray. In summary, we have indicated for the first time that M2-exo can promote osteogenic differentiation of human PDLSCs, and have revealed the functions and pathways involved in the DE-miRNAs of M0-exo and M2-exo and their downstream targets.

2022-10-31 | GSE209957 | GEO

M2-exo transfers funcional microRNA to IEC

Project description:In our study, sequencing results revealed a miRNA-mRNA modulated network in M2-exo treated IEC. This suggested that M2 macrophages load multiple miRNAs into exosomes, which then resolve ulcerative colitis by activating or inhibiting signaling pathways associated with proliferation and inflammation.

2024-08-01 | GSE223481 | GEO

Glycoproteomics of human THP-1-derived M0, M1 and M2 macrophages

Project description:In this study, we used human THP-1-derived macrophages as an immune cell model, and systematically performed glycoproteomics of three subtypes of macrophages by StrucGP.To study the N‑Glycoproteomic of them, the intact glycopeptides were first enriched and identified using triplicate mass spectrometry (MS)-based glycoproteomic approaches, then StrucGP was used for subsequent analysis. In total three subtypes of macrophages, these intact glycopeptides consist of 253 N-linked glycan structures at 652 unique glycosites from 372 N-glycoproteins, along with their PSM information. A total of 135, 163, and 201 N-glycan structures were identified from M0, M1, and M2 macrophages, respectively.

2023-10-19 | PXD030277 | Pride

Transcriptomics of M0 macrophages treated with PTEN

Project description:While naive BMDMs without further treatment are referred to as M0-like macrophages, which can be polarized to either M1-like or M2-like macrophages,To assess the consequence of PTEN binding on macrophages, we profiled the global transcriptome of M0-like BMDMs with and without PTEN treatment.

2024-07-25 | GSE249264 | GEO

Quantitative proteomic analysis of four subtypes of M2 macrophages

Project description:In this study, we used mass spectrometry and label-free quantification (LFQ) to characterize the global proteomics of polarized (M1, M2a, M2b, M2c, and M2d) and unpolarized (M0) phenotypes of macrophages from human THP-1 monocytes. The results described the biological functions of the four M2 macrophages subtypes and provided available references for identifying M2 macrophages or subtypes of M2 macrophages.

2022-08-12 | PXD022320 | Pride

Proteomic profiles of different subtypes of M2 macrophages

Project description:Bone marrow-derived macrophages (BMDMs) were isolated from C57BL/6 mice and differentiated under standard culture conditions. Upon completion of differentiation, cells were subjected to cytokine stimulation to induce distinct M2 macrophage phenotypes. Specifically, M0 macrophages were polarized into M2a macrophages with 20 ng/mL interleukin-4 (IL-4), into M2b macrophages with 100 ng/mL lipopolysaccharide (LPS) in combination with 50 μg/mL mouse immunoglobulin G (IgG), and into M2c macrophages with 40 ng/mL interleukin-10 (IL-10). Following induction, the functional heterogeneity of M0, M2a, M2b and M2c macrophages was systematically assessed through proteomic profiling. The resulting data revealed distinct protein expression patterns reflective of the specialized functional roles of each macrophage subtype.

2025-06-23 | PXD065360 |

Differentially polarized human monocyte-derived macrophages (M0, M1, M2/IL10, M2/IL4, TAM-like)

Project description:Differentially polarized human monocyte-derived macrophages (M0, M1, M2/IL10, M2/IL4, TAM-like)

| PRJNA682629 | ENA

Differentially expressed lncRNA&mRNA between macrophage M0 and macrophage M2 cells

Project description:To compare lncRNA&mRNA expression diffrence between macrophage M0 and macrophage M2 cells, we performed microarray using Arraystar Human LncRNA + mRNA Microarray v3.0 (8×60K) platform

2021-02-28 | GSE144789 | GEO

Expression analysis of microRNAs in INT-HA-induced M2-like macrophages and untreated macrophages (M0)

Project description:Expression analysis of microRNAs in INT-HA-induced M2-like macrophages and untreated macrophages (M0)

| PRJNA433494 | ENA

miRNA expression profiles of exosomes from polarized bone marrow derived macrophages

Project description:Unprogrammed macrophage polarization, is associated with diabetic wound ulcers. Nevertheless, development of corresponding drugs is still a challenge. Here, exosomes are isolated from naive bone marrow-derived macrophages (BMDMs) (M0-Exos), inflammatory BMDMs (M1-Exos), and anti-inflammatory BMDMs (M2-Exos), with the aim of pinpointing the exosomes functionality and identify global miRNAs expression profiles.

2024-06-15 | GSE234953 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data