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Lesion-remote astrocytes govern microglia-mediated white matter repair

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE312911 | GEO | 2026/01/08

REPOSITORIES: GEO

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Lesion-remote astrocytes govern microglia-mediated white matter repair I

Project description:A 50 μl spot drop containing 50,000 microglia cells was seeded into the desired wells of a 24-well plate. Cells were cultured for 7 days, with a full media change given on day 1 followed by half media change on day 4. On day 7, cells were either left untreated or treated with CCN1 (Peprotech: 120-25) at 50 ng ml−1 or vehicle (BSA) for 24 h. Each condition was carried out in triplicate for each experiment. Cells were then removed using a cell scraper, replicates pooled, and then processed for RNA-seq.

2026-01-08 | GSE312861 | GEO

Lesion-remote astrocytes govern microglia-mediated white matter repair IV

Project description:Visium Spatial Transcriptomics was applied to spared tissue regions both rostral and caudal in a mouse model of incomplete spinal cord injuryt (ISCI) at multiple timepoints after injury (3,7,28dpi) to understand spatially distinct changes occuring in spared, yet reactive, spinal tissue after ISCI.

2026-01-08 | GSE312910 | GEO

Lesion-remote astrocytes govern microglia-mediated white matter repair III

Project description:Single Nuclei RNA seq was used to examine gene expression of all spinal cord cell types from rostral and caudal spared regions of the injured spinal cord in a mouse model of incomplete spinal cord injury (iSCI, lateral hemisection) at multiple timepoints after injury (3, 7, 28 dpi). A focus of this study was to characterize spatiotemportal lesion-remote astrocyte gene expression via integration with paired spatial transcriptomics data.

2026-01-08 | GSE312880 | GEO

Lesion-remote astrocytes govern microglia-mediated white matter repair II

Project description:RNA sequencing was applied to examine changes in gene expression in astrocytes in spared tissue regions both rostral and caudal to the injury site in a mouse model of incomplete spinal cord injury (ISCI) over multiple post-injury time points. The RiboTag method was used to isolate astrocyte ribosome-associated mRNAs from the spinal cord of wild type mice and mice with astrocyte-specific conditional gene deletion (cKO) of a known transcriptional regulators of reactivity, STAT3 (Stat3 knockout: Stat3-cKO).

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Lesion-remote astrocytes govern microglia-mediated white matter repair

Project description:Lesion-remote astrocytes govern microglia-mediated white matter repair

| PRJNA1377587 | ENA

Lesion-remote astrocytes govern microglia-mediated white matter repair IV

Project description:Lesion-remote astrocytes govern microglia-mediated white matter repair IV

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Lesion-remote astrocytes govern microglia-mediated white matter repair I

Project description:Lesion-remote astrocytes govern microglia-mediated white matter repair I

| PRJNA1377527 | ENA

Lesion-remote astrocytes govern microglia-mediated white matter repair II

Project description:Lesion-remote astrocytes govern microglia-mediated white matter repair II

| PRJNA1377544 | ENA

Lesion-remote astrocytes govern microglia-mediated white matter repair III

Project description:Lesion-remote astrocytes govern microglia-mediated white matter repair III

| PRJNA1377547 | ENA

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.

Project description:The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow cytometry, we found that Treg cells infiltrated the brain 1 to 5 weeks after experimental stroke in mice. Selective depletion of Treg cells diminished oligodendrogenesis, white matter repair, and functional recovery after stroke. Transcriptomic analyses revealed potent immunomodulatory effects of brain-infiltrating Treg cells on other immune cells, including monocyte-lineage cells. Microglia depletion, but not T cell lymphopenia, mitigated the beneficial effects of transferred Treg cells on white matter regeneration. Mechanistically, Treg cell-derived osteopontin acted through integrin receptors on microglia to enhance microglial reparative activity, consequently promoting oligodendrogenesis and white matter repair. Increasing Treg cell numbers by delivering IL-2:IL-2 antibody complexes after stroke improved white matter integrity and rescued neurological functions over the long term. These findings reveal Treg cells as a neurorestorative target for stroke recovery.

| S-EPMC8282725 | biostudies-literature

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