Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [Methylation array]

ABSTRACT: Mouse tumor methylation profiling by MouseMethylation Beadchips (MM285) platform

ORGANISM(S): Mus musculus

PROVIDER: GSE312950 | GEO | 2026/02/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-02-07 | GSE275307 | GEO

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [ATAC-seq]

Project description:Pineoblastoma is a clinically aggressive childhood brain tumor composed of distinct molecular subgroups with divergent driver genes, demographics, and clinical outcomes. To identify developmental origins and mechanisms governing disease pathogenesis, we derive single-cell transcriptomes from pineal parenchymal tumors, aligning malignant cells with developmental counterparts to retrace cellular origins. Integrative computational analyses map pineoblastoma origins to transient, cycling pinealocyte progenitors during development. Lineage-specific perturbation of suspected drivers in the early pineal gland yields preclinical models representative of consensus molecular subgroups. Multi-omic characterization of patient tumors and these models uncovers a tumor-associated photoreceptor signature (TAPS) common to pineoblastoma, retinoblastoma, and Group 3 medulloblastoma. Transcriptional activity of this signature within respective cellular origins establishes a developmental basis for molecular similarities between entities. Photoreceptor signature constituents are selective dependencies across these anatomically distinct central nervous system malignancies, motivating future studies evaluating developmentally encoded programs of malignancy as potential therapeutic liabilities.

2026-02-07 | GSE318234 | GEO

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [bulkRNA-seq]

Project description:Pineoblastoma is a clinically aggressive childhood brain tumor that segregates into molecularly distinct subgroups. Mechanisms governing pineoblastoma pathogenesis, including developmental origins, remain poorly defined. Herein, we resolved the cellular composition of pineoblastoma and other pineal parenchymal tumors at single-cell resolution, aligning malignant cells with pineal gland development to retrace cellular origins. Integrative computational analyses mapped divergent pineoblastoma subgroups to cycling progenitors of the pinealocyte lineage. Lineage-specific perturbation of suspected drivers provoked the generation of genetically accurate preclinical models representing distinct molecular subgroups, while uncovering an oncogenic photoreceptor program conserved across pineoblastoma, retinoblastoma, and Group 3 medulloblastoma. Transcriptional activity of this program was acquired from cellular origin, incriminating photoreceptor identity as a common developmental vulnerability, substantiated as a strong dependency. Illuminated through multidisciplinary analysis of an uncommon, heterogeneous pediatric brain tumor, these advances motivate future studies evaluating developmentally encoded transcriptional programs of malignancy as potential therapeutic liabilities in clinically challenging entities.

2026-02-07 | GSE275306 | GEO

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [scRNA-seq]

2026-02-07 | GSE273440 | GEO

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [Methylation array]

Project description:A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [Methylation array]

| PRJNA1377649 | ENA

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

Project description:A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies

| PRJNA1150226 | ENA

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [ATAC-seq]

Project description:A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [ATAC-seq]

| PRJNA1416951 | ENA

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [bulkRNA-seq]

Project description:A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [bulkRNA-seq]

| PRJNA1150229 | ENA

A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [scRNA-seq]

Project description:A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [scRNA-seq]

| PRJNA1141927 | ENA

Mouse DNA methylation atlas using Infinium Mouse Methylation Beadchips [EPIC array profiling]

Project description:Design, annotation, and technical and biological validation of the MouseMethylation Beadchips (MM285) platform. Application of the mouse array for tissue and tumor epigenetics, comparative epigenomics, genomic imprinting, epigenetic inhibitors, PDX assessment, backcross tracing, and epigenetic clocks. The mouse data were deposited in GSE184410.

2025-11-20 | GSE310817 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data