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Distinct Transcriptomes for Cardiac Repair following multidose intramyocardial administration of Umbilical Cord Blood Mononuclear cells(UCB-MNCs)

ABSTRACT: Cardiac regeneration remains a major therapeutic challenge, and cell-based strategies offer a promising avenue. In this study, we investigated the transcriptional responses to single versus multidose intramyocardial administration of umbilical cord blood–derived mononuclear cells (UCB-MNCs) in a porcine model of right ventricular pressure overload. Transcriptome profiling revealed distinct gene expression patterns associated with repeated dosing, including activation of pathways related to cardiomyocyte proliferation, angiogenesis, and extracellular matrix remodeling. Taken together, these data provide a molecular framework for understanding how dosing strategy modulates gene expression programs during cardiac repair and identify novel targets for enhancing the efficacy of regenerative cell therapies.

ORGANISM(S): Sus scrofa

PROVIDER: GSE313521 | GEO | 2026/03/19

REPOSITORIES: GEO

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Distinct Transcriptomes for Cardiac Repair following multidose intramyocardial administration of Umbilical Cord Blood Mononuclear cells(UCB-MNCs)

Project description:Distinct Transcriptomes for Cardiac Repair following multidose intramyocardial administration of Umbilical Cord Blood Mononuclear cells(UCB-MNCs)

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Gene expression profile at single cell level of crude umbilical cord blood (UCB) and OP9 pre-conditioned UCB.

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Hydrogel-based intramyocardial delivery of antimiR-195 after ischemia-reperfusion injury [UPyPEG_IR]

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RNA-sequencing of human peripheral blood mononuclear cells (PB MNCs) and induced neural progenitor cells derived from PB MNCs

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2019-11-21 | GSE107806 | GEO

Gene expression profile at single cell level of crude umbilical cord blood (UCB) and OP9 pre-conditioned UCB.

Project description:Gene expression profile at single cell level of crude umbilical cord blood (UCB) and OP9 pre-conditioned UCB.

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Gene expression profiling in porcine chronic myocardial ischemia treated with intramyocardial injections of secretome

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Expression profile of Urothelial carcinoma of the urinary bladder (UCB) or bladder cancer from Blood

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