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Transcriptional Profiling of Zebra Finch Hypothalamus After Chronic Heat Call Exposure

ABSTRACT: Late-stage zebra finch embryos were exposed to chronic playback of parental heat calls or control sounds to test how acoustic cues of extreme heat reshape hypothalamic gene expression. RNA-seq of medial hypothalamic punches revealed modest changes in neuroendocrine genes but strong downregulation of muscle and cytoskeletal programs, with evidence of altered isoform usage and enrichment in neurovascular cell populations. These findings indicate that parental heat calls drive a non-neuroendocrine transcriptional program underlying early-life developmental plasticity and acoustic-mediated adaptation to environmental extremes in birds.

ORGANISM(S): Taeniopygia guttata

PROVIDER: GSE313742 | GEO | 2025/12/22

REPOSITORIES: GEO

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