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Single-Cell Sequencing Reveals the Immune Characteristics of Coxsackievirus A6-Associated Hand, Foot and Mouth Disease in Children

ABSTRACT: Hand, foot, and mouth disease (HFMD) is a clinically significant pediatric infection with potential neurological complications, and coxsackievirus A6 (CA6) is increasingly recognized as a predominant causative agent. We identified significant alterations in immune cell composition and amino acid metabolism during disease progression through an integrated multiomics analysis of pediatric patients with CA6-associated HFMD. Single-cell RNA sequencing revealed dynamic changes in peripheral blood mononuclear cell populations, particularly in CD4+ naïve T cells, neutrophils, and CD16- monocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE313840 | GEO | 2025/12/19

REPOSITORIES: GEO

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