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A single-cell transcriptomic atlas of the late gestation fetal brain in the pigtail macaque

ABSTRACT: The fetal brain undergoes rapid cellular and structural changes in late gestation, when waves of neurogenesis and gliogenesis shape cortical circuitry. The ventricular zone (VZ) subventricular zone (SVZ), periventricular white matter (PVWM), and deep white matter (DWM) is enriched in neuroprogenitor cells, newborn neurons, and interneurons, which are regions inaccessible to study in the third-trimester human fetal brain. The nonhuman primate (NHP) provides a powerful translational model to overcome this limitation, given its close similarity to human neurodevelopmental trajectories. The study objective was to construct a single-cell RNA-Seq (scRNA-Seq) atlas of the late gestation pigtail macaque (Macaca nemestrina) fetal brain, focusing on cells present within the VZ, SVZ, PVWM, and DWM.

ORGANISM(S): Macaca nemestrina

PROVIDER: GSE313843 | GEO | 2026/09/15

REPOSITORIES: GEO

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