Complex Human Hair Bearing Skin Organoids Reveal Cell-Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1

ABSTRACT: Epithelial surfaces are the initial site of Herpes Simplex Virus 1 (HSV-1) infection. To reflect the complexity of human skin, we used complex human hair bearing skin organoids as a new model system for HSV-1 infection. Using microscopy and spatial transcriptomics with single cell resolution, we characterize the progression of infection through the tissue as well as host cell responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE313919 | GEO | 2026/09/23

REPOSITORIES: GEO