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Transcriptomic and Epigenomic profiles analysis during human adaptation to simulated High-Altitude Hypoxia [miRNA-Seq]

ABSTRACT: Hypobaric hypoxia (HH) is characterized by reduced oxygen availability resulting from the decreased barometric pressure at high altitudes. This condition imposes substantial physiological challenges not only on populations permanently residing in high-altitude regions but also on individuals who intermittently ascend to such environments for occupational, recreational, or other purposes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE313920 | GEO | 2026/03/05

REPOSITORIES: GEO

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Transcriptomic and Epigenomic profiles analysis during human adaptation to simulated High-Altitude Hypoxia

Project description:Hypobaric hypoxia (HH) is characterized by reduced oxygen availability resulting from the decreased barometric pressure at high altitudes. This condition imposes substantial physiological challenges not only on populations permanently residing in high-altitude regions but also on individuals who intermittently ascend to such environments for occupational, recreational, or other purposes.

2026-03-05 | GSE313740 | GEO

Alterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia

Project description:For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such as erythropoiesis and overproduction of hemoglobin, however little is known on the changes of plasma proteome profiles in accommodation to high-altitude hypobaric hypoxia. In the present study, we investigated differential plasma proteomes of high altitude natives and lowland normal controls by a TMT-based proteomic approach. A total of 818 proteins were identified, of which 137 were differentially altered. Bioinformatics (including GO, KEGG, protein-protein interactions, etc.) analysis revealed the dysregulated proteins were primarily involved in complement and coagulation cascades, anti-oxidative stress and glycolysis. Validations via magnetic Luminex® Assays and ELISA demonstrated that CCL18, C9, PF4, MPO and S100A9 notably up-regulated, and HRG and F11 down-regulated in high altitude natives compared with lowland controls, which were consistent with the proteomic results. Our findings highlight the roles of complement and coagulation cascades, anti-oxidative stress and glycolysis in acclimatization to hypobaric hypoxia and provide a foundation for developing potential diagnostic or/and therapeutic biomarkers for high altitude hypobaric hypoxia-induced diseases.

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Comparative microRNA Transcriptome in Domestic Goats Reveals Adaptation to High Altitude

Project description:High-altitude adaptation is a representative example of vertebrates getting adapted to harsh and extreme environments. To investigate the miRNA expression alterations of goats that were induced by high altitude stress, we performed comparative miRNA transcriptome analysis on six hypoxia-sensitive tissues (heart, kidney, liver, lung, skeletal muscle and spleen) in two indigenous goat populations from distinct altitudes (600 m and 3000 m). We obtained the expression of 1391 mature miRNAs and identified 138 differentially expressed miRNAs between altitudes. Combined with tissue specificity analysis, we illustrated alterations of expression levels between altitudes and among tissues, which suggested the coexisting tissue-specific and tissue-conserved mechanism for hypoxia adaptation. Notably, the interplay between DE miRNA and DE target genes strongly indicated post-transcriptional regulation in HIF-1 signaling pathway, insulin signaling pathway and p53 signaling pathway, which might play a significant role in high altitude adaptation in domestic goats. These results provide insights into the complicated miRNA expression pattern and regulatory mechanism of high altitude adaptation in domestic goats.

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Project description:This study evaluates genetic and phenotypic variation in the high altitude Colla population living in the Argentinean Andes above 3500 m. They were compared to the WichÃ population living in the nearby lowlands of the Gran Chaco region. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to hypobaric hypoxia. We have genotyped 25 individuals from both populations for 730,525 SNPs. DNA from 25 saliva samples from Collas living >3500 m and 25 saliva samples from WichÃ living <500 m from the Province of Salta in Argentina was genotyped

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DNA Methylation Explains a Subset of Placental Gene Expression Differences Based on Ancestry and altitude

Project description:Investigation of how gene expression and epigenetics contribute to conservation of birth weight at high altitudes by examining mRNA and DNA methylation differences between placentas of indigenous Andeans and placentas of European descent residing at high and low altitude

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