C1q-dependent clearance of alpha-synuclein allows macrophages to transiently limit enteric synucleinopathy in male mice

ABSTRACT: Here we have utilized the 10x Chromium platform to perform single-cell RNA sequencing on immune cells isolated from mouse duodenum 30 days after inoculation with preformed fibrils of alpha-synuclein or saline (control). This is the first single-cell dataset of the immune landscape during the development of enteric synucleinopathy and thus provides novel insight into the immune response during early stages of enteric neuronal pathology.

ORGANISM(S): Mus musculus

PROVIDER: GSE314156 | GEO | 2026/01/05

REPOSITORIES: GEO