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Genome-wide binding profiles of 3xFlag-MORC1 WT and dIDR-bpNLS in doxycycline-inducible NIH3T3 cells

ABSTRACT: Doxycycline-inducible NIH3T3 cell lines expressing 3xFlag-MORC1 WT or 3xFlag-MORC1 dIDR-bpNLS were used to determine MORC1 genomic localization patterns. Cells were harvested 24 h after doxycycline induction.

ORGANISM(S): Mus musculus

PROVIDER: GSE314166 | GEO | 2026/08/12

REPOSITORIES: GEO

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Gene expression changes induced by doxycycline-inducible 3xFlag-MORC1 WT and 3xFlag-MORC1 dIDR-bpNLS expression in NIH3T3 cells

Project description:Doxycycline-inducible NIH3T3 cell lines expressing 3xFlag-mCherry (control), 3xFlag-MORC1 WT, or 3xFlag-MORC1 dIDR-bpNLS were used to evaluate transcriptional changes caused by MORC1 WT or MORC1 dIDR-bpNLS expression. Cells were harvested 48 h after doxycycline induction, and transcriptome-wide gene expression profiles were obtained.

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Chromatin accessibility changes induced by 3xFlag-MORC1 WT and dIDR-bpNLS expression in doxycycline-inducible NIH3T3 cells

Project description:Doxycycline-inducible NIH3T3 cell lines expressing 3xFlag-mCherry (control), 3xFlag-MORC1 WT, or 3xFlag-MORC1 dIDR-bpNLS were used to examine MORC1-dependent changes in chromatin accessibility. Cells were harvested 48 h after doxycycline induction.

2026-08-12 | GSE314165 | GEO

Effects of 3xFlag-MORC1 WT and dIDR-bpNLS expression on TRIM28 chromatin occupancy in doxycycline-inducible NIH3T3 cells

Project description:Doxycycline-inducible NIH3T3 cells expressing 3xFlag-mCherry (control), 3xFlag-MORC1 WT, or 3xFlag-MORC1 dIDR-bpNLS were used to assess MORC1-dependent changes in TRIM28 genomic localization. Cells were harvested 24 h after doxycycline induction.

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Gene expression changes induced by doxycycline-inducible 3xFlag-MORC1 WT and 3xFlag-MORC1 dIDR-bpNLS expression in NIH3T3 cells

Project description:Gene expression changes induced by doxycycline-inducible 3xFlag-MORC1 WT and 3xFlag-MORC1 dIDR-bpNLS expression in NIH3T3 cells

| PRJNA1390194 | ENA

Genome-wide binding profiles of 3xFlag-MORC1 WT and dIDR-bpNLS in doxycycline-inducible NIH3T3 cells

Project description:Genome-wide binding profiles of 3xFlag-MORC1 WT and dIDR-bpNLS in doxycycline-inducible NIH3T3 cells

| PRJNA1390195 | ENA

Chromatin accessibility changes induced by 3xFlag-MORC1 WT and dIDR-bpNLS expression in doxycycline-inducible NIH3T3 cells

Project description:Chromatin accessibility changes induced by 3xFlag-MORC1 WT and dIDR-bpNLS expression in doxycycline-inducible NIH3T3 cells

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Effects of 3xFlag-MORC1 WT and dIDR-bpNLS expression on TRIM28 chromatin occupancy in doxycycline-inducible NIH3T3 cells

Project description:Effects of 3xFlag-MORC1 WT and dIDR-bpNLS expression on TRIM28 chromatin occupancy in doxycycline-inducible NIH3T3 cells

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MORC1 represses transposable elements in the mouse male germ line

Project description:The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other DNA methylated and silent genes. MORC1 deficient mice were previously found to display male-specific germ cell loss and infertility. Here we show that MORC1 is responsible for transposon repression in the male germline in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homolog DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of transposons, and this is associated with failed transposon silencing at these sites. Our results identify MORC1 as an important new regulator of the epigenetic landscape of male germ cells during the period of global de novo methylation. This data includes: 47 RNA-seq, 4 smRNA-seq, 6 BS-seq, and 2 ChIP-seq datasets

2014-12-12 | E-GEOD-63048 | biostudies-arrayexpress

MORC1 represses transposable elements in the mouse male germ line

2014-12-12 | GSE63048 | GEO

Effect of Morc1 knock out on gonocyte chromatin and transcriptome [ChIP-Seq]

Project description:To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated.

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