Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [HuCCT-1]

ABSTRACT: Epigenetic alterations play an increasingly recognized role in carcinogenesis and in the development of resistance to anticancer therapies. In this study, we examined the expression of epigenetic genes to investigate their interplay in cholangiocarcinoma (CCA). We examined 257 epigenetic genes (EpiGs) in transcriptomic data from HuCCT-1 iCCA cells under hypoxia (1% O₂) for 24 h. We observed that exposing the HuCCT-1 iCCA cell line to hypoxia increased the expression of key epigenetic regulators. Our results suggest that hypoxia may contribute to the activation of a shared epigenetic program associated with malignant transformation and poor prognosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE314257 | GEO | 2026/06/25

REPOSITORIES: GEO