Species-specific splicing differences are primarily governed by changes in cis-acting sequences

ABSTRACT: We assessed whether human transcripts expressed in an aneuploid mouse that carries human chromosome 21 (HsChr21) are spliced in a human-specific or mouse-specific fashion. In almost all cases, human-specific alternative splicing is maintained in the mouse nucleus. Species-specific splicing therefore appears to be primarily directed by cis-acting elements, rather than changes in the levels or activities of trans-acting factors.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE31454 | GEO | 2012/12/01

SECONDARY ACCESSION(S): PRJNA145829

REPOSITORIES: GEO