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Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE314584 | GEO | 2026/04/03

REPOSITORIES: GEO

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Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

Project description:Idiopathic pulmonary fibrosis (IPF) is a devastating pulmonary disease with no curative treatment other than lung transplantation. IPF results from maladaptive responses to lung epithelial injury, but the underlying mechanisms remain unclear. Here, we show that deficiency in the innate immune receptor, toll-like receptor 5 (TLR5), is associated with IPF in humans and with increased susceptibility to experimental fibrosis in mice, while activation of lung epithelial TLR5 through a synthetic flagellin analog protects from experimental fibrosis. Mechanistically, epithelial TLR5 activation induces antimicrobial gene expression and ameliorates dysbiosis after lung injury. In contrast, TLR5 deficiency in mice and IPF patients is associated with lung dysbiosis. Elimination of the microbiome in mice through antibiotics abolishes the protective effect of TLR5 and reconstitution of the microbiome rescues the observed phenotype. In aggregate, TLR5 deficiency is associated with IPF and dysbiosis in humans and in the murine model of pulmonary fibrosis. Furthermore, TLR5 protects against pulmonary fibrosis in mice, and this protection is mediated by effects on the microbiome.

2026-04-03 | GSE314583 | GEO

Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

Project description:TLR5 is a pathogen recognition receptor against flagellin that is expressed in various epithelial and immune cells. Mice pretreated with TLR5-agonist are protected against bleomycin-induced pulmonary fibrosis. However, the mechanisms by which TLR5-agonism protects against pulmonary fibrosis remains to be determined. Here, we found innate host defense gene sets to be selectively elevated in sorted type 2 alveolar epithelial.

2026-04-03 | GSE314582 | GEO

Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

Project description:Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

| PRJNA1391554 | ENA

Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

Project description:Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

| PRJNA1391547 | ENA

Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

Project description:Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis

| PRJNA1391551 | ENA

Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection.

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Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury.

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Toll-Interacting Protein and Altered Lung Microbiota in Idiopathic Pulmonary Fibrosis.

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Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity

Project description:Comparison of gene expressions between the lungs of CD9KO and CD151KO mice A microarray study identified an enrichment of genes involved in connective tissue disorders in the lungs of CD151 KO mice, but not in CD9 KO mice.

2020-10-20 | GSE159236 | GEO

Jinlian Xiaodu Decoction Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats.

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