Synovial transcriptomic response to intra-articular 2.5% polyacrylamide hydrogel in equine experimental osteoarthritis [RNAseq_SF]

ABSTRACT: Background - Osteoarthritis (OA) represents one of the most common conditions treated by equine practitioners. Despite this high prevalence, no approved pharmacological intervention, biological therapy, or procedure prevents or reverses progressive destruction of degenerative joints. Intra-articular injectable polyacrylamide hydrogels (iPAAG), which consist of biocompatible non-degradable synthetic polymers, have been introduced with reported clinical efficacy. However, their potential mechanisms of action have not been fully investigated. Objectives – To determine differential gene expression in synovial tissues following intra-articular injection of 2.5% iPAAG in experimentally induced equine OA. Study Design – Prospective randomized placebo-controlled longitudinal cohort study.

ORGANISM(S): Equus caballus

PROVIDER: GSE314612 | GEO | 2026/07/30

REPOSITORIES: GEO