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Transcriptional Response to Combination Antiretroviral Therapy Predicts Side Effects and Novel Targets

ABSTRACT: Antiretroviral therapy (ART) has revolutionized the clinical management of people with human immunodeficiency virus (HIV), transforming HIV infection into a chronic condition. Yet, the mechanisms of action and off-target effects of modern combination ART regimens versus individual ART medications are not fully understood. We found that ART regimens affected transcriptional signatures of genes involved in HIV-host PPIs and were less tied to common ART-related side effects. Our findings support the use of high-throughput transcriptomics to detect specific mechanisms of ART on- and off-target effects to help prioritize new drug targets and compounds in future development and optimization of safer and more efficient ART.

ORGANISM(S): Homo sapiens

PROVIDER: GSE314659 | GEO | 2026/02/11

REPOSITORIES: GEO

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