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Transcriptomic profiling of oxaliplatin-resistant colorectal cancer cells

ABSTRACT: RNA-seq analysis comparing parental HCT116 cells with oxaliplatin-resistant HCT116-OXR cells to identify molecular mediators of platinum resistance in colorectal cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE314768 | GEO | 2026/04/01

REPOSITORIES: GEO

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	GSE314768_HCT116_HCT116OXR_gene_expression_counts.txt.gz	Txt

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Differential ncRNAs of oxaliplatin-resistant versus parental HCT116 cells

Project description:Oxaliplatin resistance frequently leads to therapeutic failure in colorectal cancer (CRC). Increasing evidence has shown that noncoding RNAs (ncRNAs) play pivotal roles in chemoresistance of CRC. However, the roles and mechanisms of ncRNAs in oxaliplatin resistance are not well understood. In this study, to identify the ncRNAs induced by oxaliplatin, we profile the expression of ncRNAs in oxaliplatin-resistant HCT116 CRC cells (HCT116oxR) and parental HCT116 cells using next-generation sequencing technology.

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