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Nutrigenomic Influence of a Curcumin-Supplemented High Glycemic Diet on Hippocampal Microvasculature in Male C57BL/6J Mice

ABSTRACT: Curcumin, a dietary polyphenol primarily derived from turmeric, has potent antioxidant and anti-inflammatory capabilities against diet-related chronic diseases. A high glycemic diet (HGD) has been shown to contribute to cognitive decline and dysfunction of murine brain microvasculature. The goal of our study was to elucidate the multi-genomic effects of curcumin on hippocampal microvessels in mice during consumption of a high glycemic diet. The HGD + Curc treatment influenced the differential expression of 1887 genes compared to HGD alone, of which 307 overlapped and were negatively correlated with the fold change expression of the HGD versus LGD comparison. These protein coding and non-coding gene targets modulated by HGD+Curc were involved in pathways related to neurodegeneration, oxidative phosphorylation, cell signaling, and cellular metabolism. The results from this study show that curcumin induces complex nutrigenomic modifications that could elucidate its neuroprotective effect against hippocampal microvascular dysfunction induced by a high glycemic diet. The gene expression data of the low glycemic diet (LGD, 12% sucrose) and high glycemic diet (HGD, 34% sucrose) can be found in GEO dataset GSE185057

ORGANISM(S): Mus musculus

PROVIDER: GSE314833 | GEO | 2026/02/25

REPOSITORIES: GEO

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