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Compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/- mediated clonal hematopoiesis

ABSTRACT: Here, we use single cell sequencing to elucidate the role and heterogeniety of the bone marrow cells in clonal hematopoiesis. We have identified key CD74/CD206 macrophage populations that play a role in early clonal propagation of Tet2+/- cells and analyzed their expression at both week 1 and week 22 of clonal hematopoiesis progression.

ORGANISM(S): Mus musculus

PROVIDER: GSE314864 | GEO | 2026/05/15

REPOSITORIES: GEO

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