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S-1 plus chidamide combined with envafolimab as second-line treatment in advanced and metastatic pancreatic cancer (P-henomS/SCOG-P002): A single-arm, exploratory, multicenter, phase 2 trial

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with a generally poor prognosis, and there are few effective second-line treatment regimens. We conducted a single-arm, multicenter, prospective Phase II trial (ChiCTR2200058431) evaluating the efficacy and safety of S-1 plus chidamide combined with envafolimab in patients with metastatic PDAC.10×scRNA-seq was adopted to conduct an initial exploration into the potential mechanisms underlying the efficacy of the combination regimen.

ORGANISM(S): Mus musculus

PROVIDER: GSE315053 | GEO | 2026/01/05

REPOSITORIES: GEO

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