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Effects of oxytocin receptor agonists on the hair growth ability of dermal papilla cells

ABSTRACT: We examined effects of oxytocin receptor agonists on the hair growth ability of dermal papilla cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315061 | GEO | 2025/12/31

REPOSITORIES: GEO

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Effects of oxytocin receptor agonists on the hair growth ability of dermal papilla cells

Project description:Effects of oxytocin receptor agonists on the hair growth ability of dermal papilla cells

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Effects of oxytocin on the hair growth ability of dermal papilla cells

Project description:Oxytocin (OXT) is a neuropeptide hormone termed “love hormone” that is produced and released during childbirth and lactation. It is also produced in response to stimulation of the skin (e.g., during hugging and massaging) and music therapy, among others. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells, that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP functional markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of hair growth-promoting factors including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia.

2024-12-01 | GSE233904 | GEO

Effects of oxytocin on the hair growth ability of dermal papilla cells

Project description:Effects of oxytocin on the hair growth ability of dermal papilla cells

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Effects of WAY267464 or LIT001 on the hair growth ability of dermal papilla cells

Project description:We examined effects of WAY267464 or LIT001 on the hair growth ability of dermal papilla cells.

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Global profiling of human hair follicle scalp dermal papilla cells using Affymetrix microarrays

Project description:Dermal papilla cells isolated from the human hair follicle are capable of inducing hair growth in recipient epithelia. However, demonstrating disparity from rodent dermal papilla, human cells lose this inductive competance immediately upon growth in culture under normal growth conditions. We grew dermal papilla cells in hanging drop cultures that are morphologically akin to intact dermal papilla, and found that by enhancing the environment for aggregation, we could restore the inductive capacity of human dermal papilla cells in culture. The underlying genes that regulate the inductive potential of dermal papilla cells is not well understood, and we sought to use global profiling to identify key genes and pathways related to inductive competance within dermal papilla cells. We used Affymetrix microarrays to profile human dermal papilla cells in both hair inducing, and non-hair inducing states. Affymetrix microarrays were used to to perform profiling of human dermal papilla cells, both as intact tissues (freshly isolated from scalp), and at several stages in subsequent two dimensional culture; cell explant outgrowths (p0), cells at passage 1 (p1), passage 3 (p3) and passage 5 (p5). RNA was isolated from cultured cells 72 hours after feeding. Cells at passage 3 were also grown in hanging drops to form dermal spheroids, that were used for RNA collection 48 hours after establishment. All experiments were performed using tissue from three biological replicates (#D5, D6, D7),

2013-10-20 | E-GEOD-44765 | biostudies-arrayexpress

Effects of cinnamic acid on the hair growth ability of dermal papilla cells

Project description:We examined effects of cinnamic acid on the hair growth ability of dermal papilla cells. Treatment with cinnamic acid led to upregulation of G-protein coupled receptor signaling pathway and neuroactive ligand-receptor interaction in human DP cells.

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Global profiling of human hair follicle scalp dermal papilla cells using Affymetrix microarrays

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Serotonin activates dermal papilla cells and promotes hair growth

Project description:We examined effects of serotonin (5HT) or sumatriptan on the hair growth ability of dermal papilla cells.

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Gene expression profiling of adult hair follicle dermal stem cells and progeny, dermal sheath and dermal papilla cells

Project description:Here we have developed a novel FACS strategy to prospectively isolate hair follicle dermal stem cells, dermal sheath and dermal papilla cells from adult skin initiating synchronous hair follicle regeneration and identified Hic1 as a marker of hfDSCs and Rspondins as stimulators of hfDSCs and epithelial cells, and subsequently hair follicle regeneration

2020-02-03 | GSE109256 | GEO

Effects of oxytocin on the hair growth ability of dermal papilla cells.

Project description:Oxytocin (OXT) is a neuropeptide hormone termed "love hormone" produced and released during childbirth and lactation. It is also produced in response to skin stimulation (e.g., during hugging and massaging) and music therapy. The effects of OXT on various organs have been revealed in recent years; however, the relationship between hair follicles and OXT remains unclear. In this study, we examined the effects of OXT on dermal papilla (DP) cells that control hair growth by secreting growth/regression signals. Gene expression analysis revealed that DP signature markers were significantly upregulated in DP cells treated with OXT. In addition, we tested the hair growth-promoting effects of OXT using in vitro hair follicle organoids. OXT promoted the growth of hair peg-like sprouting by upregulating the expression of growth-promoting factors, including genes encoding vascular endothelial growth factor A (VEGFA). This study highlights the positive effects of OXT in hair follicles and may assist in the development of new treatments for alopecia.

| S-EPMC10589336 | biostudies-literature

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