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Protective Mechanisms of SP1-Induced PRDX6 Expression Against Ferroptosis in Retinal Pigment Epithelium

ABSTRACT: Background: Retinitis pigmentosa is a polygenic genetic disease for which night blindness and progressive visual field shrinkage are the primary clinical manifestations. The pathogenesis of retinitis pigmentosa involves pathological changes in photoreceptor and retinal pigment epithelium (RPE) cells. Ferroptosis, a form of programmed cell death distinct from apoptosis, is related to retinitis pigmentosa via certain pathological mechanisms. PRDX6 is a negative regulator of ferroptosis, the expression of which is modulated by SP1. In this study, we investigated the protective mechanism of PRDX6 on retinitis pigmentosa, and examined the guiding effect of SP1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315262 | GEO | 2026/05/06

REPOSITORIES: GEO

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