Recurrent FOXA1 mutation redirects NIPBL chromatin distribution

ABSTRACT: A recurrent FOXA1 mutation (R219S) in prostate cancer redirects FOXA1-NIPBL to TAD boundaries by recognizing a non-canonical motif, fostering a more insulated and tumor-aggressive genome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315393 | GEO | 2026/05/06

REPOSITORIES: GEO